Some of the central molecular mechanisms that lead to hyperalgesia and allodynia after peripheral tissue injury involve the spinal dorsal horn transient receptor potential vanilloid 1 (TRPV1).

9 Central sensitisation can be seen as an umbrella term,9 the main characteristics of which are: Hyperalgesia is an increased pain response to normally painful stimuli and may be as a result of ...

Chronic pain is a long-term condition that can persist for weeks, months, or even years. It can stem from a variety of ...

The following is a summary of “Effect of limb position change on capsaicin-evoked pain: Evidence of interplays between the ...

The Doyle lab studies the pathophysiological and signaling mechanisms (e.g. glutamatergic signaling, neuroinflammation and nitro-oxidative stress) common to the development of cognitive impairment, ...

Stress can also be a limiting factor for sleep and increase pain levels. “In patients with chronic pain, stress is generally associated with a worsening of pain symptoms and stress-induced ...

The presence of an initiating noxious event or a cause of immobilization. Continuing pain, allodynia, or hyperalgesia with which the pain is disproportionate to the inciting event. Evidence at ...

In doing so, it reduces a dog’s ability to perceive pain. Some painful conditions vets might treat with gabapentin include chronic arthritis, pain associated with cancer, and hyperalgesia - which is a ...

Opioid-induced hyperalgesia (OIH) and allodynia; consider decreasing dose of current opioid or opioid rotation if OIH is suspected. COPD, cor pulmonale, decreased respiratory reserve, hypoxia ...

Trevena's discovery efforts have identified a family of compounds that are highly selective for the S1P 1 receptor. TRV045 reversed thermal hyperalgesia, a measure of neuropathic pain, in nonclinical ...