The type 1 IGF receptor (IGF-IR) is activated by two ligands, IGF-1 and IGF-2, and by insulin at supraphysiological concentrations. It plays a significant role in the growth of normal and abnormal ...
Insulin-like growth factor 1, also known as IGF-1, is a crucial hormone that significantly affects muscle development and rejuvenation. This hormone is generated by the liver in response to the ...
IRS-1 effects on cells can be dissociated from the effects of the IGF-IR, IRS-2 and insulin receptor. IRS-1 is a biomarker of sensitivity of cancer cells to IGF-IR targeting. Hypothesis ...