Skin pigmentation disorders affect people across the world. One of them, vitiligo, is said to have a worldwide incidence of 1 ...

In particular, by suppressing MMP2, the hope is that pigment-producing cells will return to the skin.” Reference: Yang F, ...

Skin pigmentation disorders affect people across the world. One of them, vitiligo, is said to have a worldwide incidence of 1-2%.

Skin pigmentation disorders affect people across the world. One of them, vitiligo, is said to have a worldwide incidence of 1-2%. What causes the loss ...

This process has been linked to the induction of HIF1α and the activation of MMP2/9. "In an attempt towards the therapeutic approach, we have demonstrated that Dialyl-sulfide is a good inducer of ...

在癌症治疗的不断探索中，针对 Trop-2 的抗体药物偶联物（ADC）成为了新的研究焦点。近日，国际知名期刊 International Journal of Molecular Sciences 在线发表了一篇综述文章，由 Tomas Koltai ...

【导读】结直肠癌（CRC）是全球第二大癌症相关死亡原因。虽然手术切除和免疫疗法提高了CRC患者的生存率，但转移和复发仍然是导致预后不良的主要问题。因此，探索发病机制并识别特异性生物标志物对于CRC的早期诊断和靶向治疗至关重要。

RECK (reversion including cysteine-rich protein with kazal motifs). This membrane-bound glycoprotein inhibits MMP2, -9 and -14. RECK probably has other functions, because a null mutation in the ...

As noted above, stellate cell activation is the central event in hepatic fibrosis. Activation consists of 2 major phases: (1) initiation (also called apreinflammatory stage) and (2) perpetuation ...

BMS-561392 (compound 3 in Table 2, Figure 2) is an orally active, partially selective inhibitor of TACE. [19] It also targets MMP3 and MMP12 as well as ADAMTS4 (ADAM with thrombospondin motifs 4 ...

An Osaka Metropolitan University-led team has uncovered clues to the mechanism behind vitiligo, a skin pigmentation disorder ...