A new study in mice shows how the small GTPase Cdc42 influences bone modeling and remodeling—it modulates both the formation and function of osteoclasts, and is involved in the downstream ...

In this study, the researchers constructed a light-activated form of RANK, an important signaling protein in osteoclast differentiation. They then expressed this optogenetic protein, called Opto-RANK, ...

And finally, you know, if we're targeting that osteoclast, there may be other ways of speaking to the osteoclast, through other kinds of signaling, and there are drugs like that, that are in the ...