Activation of macrophage TLR4 by bacterial endotoxins is important for the progression of sepsis, but the underlying ...

Innovative use of lipid nanoparticles to deliver immune agonists shows promise in activating anti-tumor immunity in ...

Catharina Svanborg and colleagues have shown that differential expression of Toll-like receptor 4 (TLR4), driven by variations in the sequence of the gene's promoter, affects the magnitude of the ...

The leading Toll-Like Receptor 4 (TLR-4) Agonist Companies such as Eisai, Akaza Bioscience, OPNT-003, GeNeuro, MN-166 ...

In addition, Poltorak et al. (1998) demonstrated that mice with a defective version of TLR4 are completely resistant to LPS-induced sepsis. This established that TLR4 is the receptor for LPS ...

Results Our results demonstrate that TLR4 is expressed in human and mouse skeletal muscle fibres, and coexpressed with MHC-class I in muscle fibres of patients with myositis. Furthermore, we show that ...

They found that microbes from aged mice were more likely than those from young mice to activate TLR4, which can sense ...

There are several TLR receptors that each recognize a specific molecule. In 2010, researchers showed that the receptor TLR4 is responsible for causing inflammation in the lung after exposure to ...

2016年11月14日，四川大学华西医院神经疾病研究所&昆明医科大学在Molecular Neurobiology (中科院二区 IF=4.6)刊上在线发表题为 "LPS Pretreatment Provides Neuroprotective ...

Background Pattern recognition receptors like NKG2D [1] and TLR4 [2] together with chemokine receptors like CX3CR1 [3] are important mediators of innate immunity. Objectives The study was performed to ...

马萨诸塞大学的研究人员近日在小鼠身上展示了一种抗击胰腺癌的新方法。这项研究成果发表在《Science Translational Medicine》杂志上，概述了一种新型的纳米颗粒药物递送系统与肿瘤靶向药物的协同效应。