GalNAc, or N-acetylgalactosamine, a type of sugar molecule, is used by RNA-interference drug developers e.g., Alnylam Pharmaceuticals, Inc. (ALNY) in several of its approved drugs that target ...

The most successful method to date uses the N-acetylgalactosamine (GalNAc) ligand which, when conjugated to RNA moieties, allows cellular uptake, but only into liver hepatocytes. A few RNA ...

Sirnaomics raised the money to advance a pipeline of drug candidates underpinned by its polypeptide nanoparticle (PNP) and GalNAc (N-Acetylgalactosamine) technology platforms (Fig. 1). PNP offers ...

To demonstrate how this can work, Andersson pointed to results from a study into the targeted delivery of a promising liver-targeted N-acetylgalactosamine (GalNAc) conjugated antisense ...

A very large family of ppGalNAc transferases (>16) initiates mucin-type O-glycan by adding N-acetylgalactosamine (GalNAc) to peptide Ser and Thr residues. Homologous family members are found over a ...

Identification of potent COVID-19 main protease inhibitors by loading of favipiravir on Mg12O12 and Zn12O12 nanoclusters: an in silico strategy for COVID-19 treatment.