分化为胚胎上皮细胞（epiblast，Epi）和原始内胚层（primitive endoderm，PrE）。这一过程中，胚胎保持了一段时间的多能性（plasticity），即在实验条件下 ...

Chemicals were then used to coax these stem cells into becoming four types of cell found in the earliest stages of the human embryo: epiblast cells, which become the embryo proper (or foetus ...

The Vierbuchen laboratory seeks to elucidate fundamental mechanisms governing the production of the myriad neuronal cell types required to build functioning neural circuits. To model these dynamic ...

Each time, the cell closest to the bead (the proximal cell) maintained the characteristics of an embryonic stem cell, while the distant (or distal) cell turned on genes indicating it had begun to ...

The first wave channels glucose through the hexosamine biosynthetic pathway (HBP) in epiblast cells, facilitating the formation of proteoglycans for fibroblast growth factor (FGF) signaling.

But to maximize their potential, scientists needed to understand how to apply their mouse-cell knowledge to these stem cells. Tesar's breakthrough discovery of an additional type of cell—epiblast stem ...

This work is an important contribution to understanding the role of FGF signaling in the induction of primitive-like cells in a 2D system of human gastrulation. The authors provide compelling evidence ...

7.Sugimoto M, Kondo M, Koga Y, Shiura H, Ikeda R, Hirose M, Ogura A, Murakami A, Yoshiki A, Chuva de Sousa Lopes SM, Abe K. "A simple and robust method for establishing homogeneous mouse epiblast stem ...

Between 1972 and 1976, Stevie Wonder released five albums – culminating in his "magnum opus" "Songs in the Key of Life" – that "turned him into a one-man pop colossus", said Fiona Sturges in the ...