Chemicals were then used to coax these stem cells into becoming four types of cell found in the earliest stages of the human embryo: epiblast cells, which become the embryo proper (or foetus ...

The first wave channels glucose through the hexosamine biosynthetic pathway (HBP) in epiblast cells, facilitating the formation of proteoglycans for fibroblast growth factor (FGF) signaling.

Tesar's breakthrough discovery of an additional type of cell—epiblast stem cells from early mouse embryos—effectively bridged the critical gap. These cells closely resembled human embryonic stem cells ...

cell turned on genes indicating it had begun to differentiate into the more specialized cell known as an epiblast stem cell. “That makes sense,” Nusse says, “because the Wnt signal is important for ...

By contrast, in the epiblast (green cells), yet another round of reactivation takes place in preparation for a final round of inactivation in the form of random X-chromosome inactivation.

Medina-Cano D, Corrigan EK, Glenn RA, Islam MT, Lin Y, Kim J, Cho H, Vierbuchen T. (2022) Rapid and robust directed differentiation of mouse epiblast stem cells into definitive endoderm and forebrain ...

分化为胚胎上皮细胞（epiblast，Epi）和原始内胚层（primitive endoderm，PrE）。这一过程中，胚胎保持了一段时间的多能性（plasticity），即在实验条件下 ...

Between 1972 and 1976, Stevie Wonder released five albums – culminating in his "magnum opus" "Songs in the Key of Life" – that "turned him into a one-man pop colossus", said Fiona Sturges in the ...

This work is an important contribution to understanding the role of FGF signaling in the induction of primitive-like cells in a 2D system of human gastrulation. The authors provide compelling evidence ...

"A simple and robust method for establishing homogeneous mouse epiblast stem cell lines by wnt inhibition." Stem Cell Reports 4, 744-57 (2015). 8.Mekada K, Hirose M, Murakami A, Yoshiki A.