Glycans are chains of sugars that attach to cells through proteins or lipids, changing their chemical characteristics.

Mature N-linked glycans are generated from the differential and sequential action of glycosidases and glycosyltransferases in the ER and the Golgi apparatus, and typically fall into either high ...

Glycosylation is the reaction catalysed by glycosyltransferases, which adds carbohydrates site-specifically to another molecule, generally proteins and lipids. Glycosylation comes in five forms ...

A major focus of our work is on POGLUT1 and other glycosyltransferases responsible for the addition of O-linked glycans to epidermal growth factor-like (EGF) repeats. Specifically, we would like to ...

Unlike other biomolecules, glycans are not directly encoded by DNA in the genome. Instead, they are built from simple building blocks by molecular machines called glycosyltransferases. When ...