引言通过化学小分子诱导靶蛋白和E3泛素连接酶的相互作用，从而实现靶蛋白的特异性降解是一种新兴的药物开发模式，为传统上被认为“难以成药”的靶点提供了全新的解决方案。当前用于靶向蛋白降解的化学分子主要分为两类：蛋白降解靶向嵌合体(PROTAC)和分子胶( ...

The AI tool AlphaFold has been improved so that it can now predict the shape of very large and complex protein structures.

Researchers from Linköping University enhanced the AI tool AlphaFold to predict the shape of extremely large and complex ...

The AI tool AlphaFold has been improved so that it can now predict the shape of very large and complex protein structures. Linköping University researchers have also succeeded in integrating ...

ACS Chem Biol. 2010 Apr 16;5(4):359-64. Janowiak BE*, Fischer A*, Collier RJ., Effects of introducing a single charged residue into the phenylalanine clamp of multimeric anthrax protective antigen. J ...

Jennifer Hudson‘s first Christmas album, The Gift of Love, has debuted on Billboard’s Top Holiday Albums chart this week. The ...