Pathways known to be important in myofibroblast biology, such as transforming growth factor beta and Rho kinase, are challenging to target because of their important pleiotropic contributions to ...

Our lab is developing an experimental model to define how alterations of the biochemical and biophysical cellular microenvironment can stimulate myofibroblast development and activation, and how ...

Newcells Biotech (“Newcells”), a leading drug discovery partner specializing in the development of in vitro models and ...

His team has honed in on a process of transdifferentiation of ocular cells to a myofibroblast, which is a type of cell that specializes in extracellular matrix production, modification and subsequent ...

HAYA is developing a pipeline of lncRNA-targeting candidates for the tissue-specific treatment of fibrotic diseases in ...

F.M. Yavitt, B.E. Kirkpatrick, M.R. Blatchley, K.F. Speckl, E. Mohagheghian, R. Moldovan, N. Wang, P.J. Dempsey and K.S. Anseth, “In situ modulation of intestinal ...

As society ages, the number of patients with heart failure is rapidly increasing. Excessive growth of fibrotic tissue in the ...

The enzyme protein kinase N (PKN) has been implicated in a signaling cascade that causes heart fibroblast activation. A group ...

Endothelial-to-mesenchymal transition (EndoMT) is a transdifferentiation by which endothelial cells (ECs) lose their specific morphology/markers and acquire myofibroblast-like features. Here, we ...

today announced the launch of its imaging suite and advanced lung Fibroblast-to-Myofibroblast Transition (FMT) assay. MicrosensDx is excited to announce that it is working with The Mayr Group at ...

Slight increases in myofibroblast numbers were also obtained in cGvHD and Tsk-1 models. CD31 staining revealed significant loss of capillaries in SSc hearts (2.16±0.17 fold change vs controls p<0.0001 ...