As its name suggests, the fifth histone is associated with the linker DNA that extends between nucleosomal core particles. We will use the name 'linker histone' to include all the closely related ...

58 Purified recombinant MeCP2 was assembled onto nucleosomal arrays, and the resulting nucleoprotein structures were characterized using analytical ultracentrifugation, agarose gel electrophoresis ...

Implications for gene regulation and biomedicine The study demonstrates that nucleosomal architecture is greatly influenced by the DNA sequence and physical signals that are emitted by the ends of ...

Our group applies structural (cryo-EM, x-ray crystallography and NMR), biochemical and biophysical methods together with functional studies to investigate macromolecular-mediated recognition, ...

The study demonstrates that nucleosomal architecture is greatly influenced by the DNA sequence and physical signals that are emitted by the ends of the genes. These signals determine the location ...

Jude Department of Structural Biology. "This strategy allowed us to discover that the first binding event of Oct4 positions the nucleosomal DNA in a manner that allows cooperative binding of ...

Yeying Huang, R. Taylor Durall, Nhi M. Luong, Hans J. Hertzler, Julianna Huang, Prafulla C. Gokhale, Brittaney A. Leeper, Nicole S. Persky, David E. Root, Praju V ...