德国Max delbrck中心Michael Sigal实验室和柏林慈善医院的研究人员在《科学进展》杂志上发表了一项研究结果，阐明了p53基因在溃疡性结肠炎中的作用，提出了一种潜在的新药靶点，可以阻止疾病发展为癌症。

The findings offer a promising drug target to prevent progression to colon cancer by targeting abnormal cells early on.

本研究强调了TRIM33介导的P53翻译后调控在有氧糖酵解和食管鳞状细胞癌肿瘤进展中的重要性。TRIM33的表达可以作为评估癌变风险的早期生物标志物，并作为食管鳞状细胞癌的干预靶点，为靶向葡萄糖代谢的癌症治疗提供了一种选择。

The study emphasises on the role of the p53 tumor suppressor gene in the pathogenesis of ulcerative colitis - an inflammatory bowel disease.

Researchers in the lab of Michael Sigal at the Max Delbrück Center and Charité – Universitätsmedizin Berlin have elucidated ...

Results provide a mechanistic explanation of why early loss of p53 signaling is frequently observed in UC-associated ...

New research highlights a pivotal role for the p53 gene in ulcerative colitis progression, offering a potential therapeutic ...

药物的研发往往会耗费大量人力物力，还得关注后续对人体其他副作用的影响、提高体外安全性。激酶谱筛选不仅可以确定药物的作用靶点，而且帮助药物研发人员找出高抑制率的非作用靶点，注意脱靶效应，以免对人体产生其他副作用。进行广泛的激酶谱分析可以揭示其对非靶标激 ...

研究发现了可用于肿瘤干预的p53-SET-PP2A反馈调节环路。研究人员设计联合应用p53激活剂和SET拮抗剂，发现两者能够产生协同抑制肿瘤的生物学效应 ...

p53 lies at the hub of a vast signalling network. Polymorphisms in upstream activators, repressors or downstream effectors of p53 might individually modulate cancer risk or interact with ...

In a recent perspective published in the journal Cell Death and Differentiation, researchers in France, Germany, and Sweden ...

p53 is a common denominator among human cancers. How was it discovered? What are the persistent questions about its function? Aa Aa Aa It seems nearly impossible for a normal cell to become a ...