德国Max delbrck中心Michael Sigal实验室和柏林慈善医院的研究人员在《科学进展》杂志上发表了一项研究结果，阐明了p53基因在溃疡性结肠炎中的作用，提出了一种潜在的新药靶点，可以阻止疾病发展为癌症。

The findings offer a promising drug target to prevent progression to colon cancer by targeting abnormal cells early on.

本研究强调了TRIM33介导的P53翻译后调控在有氧糖酵解和食管鳞状细胞癌肿瘤进展中的重要性。TRIM33的表达可以作为评估癌变风险的早期生物标志物，并作为食管鳞状细胞癌的干预靶点，为靶向葡萄糖代谢的癌症治疗提供了一种选择。

The study emphasises on the role of the p53 tumor suppressor gene in the pathogenesis of ulcerative colitis - an inflammatory bowel disease.

Researchers in the lab of Michael Sigal at the Max Delbrück Center and Charité – Universitätsmedizin Berlin have elucidated ...

Results provide a mechanistic explanation of why early loss of p53 signaling is frequently observed in UC-associated ...

New research highlights a pivotal role for the p53 gene in ulcerative colitis progression, offering a potential therapeutic ...

药物的研发往往会耗费大量人力物力，还得关注后续对人体其他副作用的影响、提高体外安全性。激酶谱筛选不仅可以确定药物的作用靶点，而且帮助药物研发人员找出高抑制率的非作用靶点，注意脱靶效应，以免对人体产生其他副作用。进行广泛的激酶谱分析可以揭示其对非靶标激 ...

研究发现了可用于肿瘤干预的p53-SET-PP2A反馈调节环路。研究人员设计联合应用p53激活剂和SET拮抗剂，发现两者能够产生协同抑制肿瘤的生物学效应 ...

p53 lies at the hub of a vast signalling network. Polymorphisms in upstream activators, repressors or downstream effectors of p53 might individually modulate cancer risk or interact with ...

▲ 点击上方蓝字关注CellPress细胞科学 ▲生命科学Life science近日，阿肯色医科大学的湛凤凰教授和南华大学衡阳医学院的夏机良教授联合在Cell Press细胞出版社旗下期刊Trends in Molecular ...

p53 is a common denominator among human cancers. How was it discovered? What are the persistent questions about its function? Aa Aa Aa It seems nearly impossible for a normal cell to become a ...