So, proteinases provide an important control that regulates the varied cellular processes defining inflammation. Matrix metalloproteinases (MMPs) constitute a family of 24 mammalian extracellular ...

Proteolytic enzymes, also called proteases, peptidases or proteinases, are enzymes that hydrolyze peptide bonds of peptides and proteins. Proteases are classified into families based on their ...

Inflammatory cells are recruited to the site of injury to provide defence against invading pathogens, as well as the necessary cytokines, growth factors and proteinases that are required for new ...

These proteinases can also be visualized with molecular imaging techniques that are being developed in conjunction with Dr. Weissleder. And these techniques are really a very promising way of ...

The capsids of non-enveloped viruses are highly multimeric and multifunctional protein assemblies that play key roles in viral biology and pathogenesis. Despite their importance, a comprehensive ...

BACKGROUND The matrix metalloproteinase (MMP) enzymes MMP-3 and MMP-9 have relevance to the chronic structural airway changes in asthma. These proteinases can be generated by structural and ...

These cells deploy complex cytoskeletal rearrangements to recognize and eliminate potential threats 3. Even in the steady state, myeloid cells constantly survey their surroundings for potential ...

No significant effects were seen in the AIA model. No toxic effects were seen in all three animal models. Conclusion Although several MMPs in concert with other proteinases have a role in the process ...

My group is interested in understanding the role of extracellular matrix internalisation in invasive cell migration and cell growth. The extracellular matrix (ECM) is a complex network of secreted ...

ALA = Amoebic liver abscess; Eh = Entamoeba histolytica; EhCP = E. histolytica cysteine proteinase; Ehserp = E. histolytica serine proteinase; EhSTIRP = Serine threonine isoleucine-rich protein ...

Human respiratory syncytial virus (hRSV) not only affects newborns but also older adults, contributing to a substantial worldwide burden of disease. However, only three approved hRSV vaccines remain ...