Thiopurines are potentially hepatotoxic agents that interact with T lymphocytes. The active metabolite of thiopurines, 6-thioguanin, has proapoptotic properties. Thiopurines, therefore ...

Researchers analyzed whole-genome sequencing data from 76,805 patients to identify variants in 4 genes that are associated ...

In Prometheus v. Mayo (see page 1243), Prometheus Laboratories battled the Mayo Clinic over drug dosing tests that measure metabolites produced after administering thiopurines, which are used to ...

a FDA = Food and Drug Administration; CYP2C9 = cytochrome P-450 isoenzyme 2C9; VKORC1 = vitamin K epoxide reductase complex subunit 1; UGT1A1 = uridine diphosphate-glucuronosyltransferase 1A1 ...