The present study quantifies the impact of the presence of tophi and frequency of acute gout attacks on health-related quality of life (HRQOL), productivity, and healthcare resource utilization.

Creatinine clearance was the major factor independently associated with early presentation with tophi. Although other factors such as diuretic use and older age were associated with presence of ...

He had a prior history of coronary heart disease, high-grade ischemic cardiomyopathy, chronic renal failure, and chronic gouty arthritis with multiple gouty tophi. He had also had hyperuricemia ...

Many people with gout don’t have any symptoms between flares. If you have untreated gout for a long time, something called tophi can develop. Tophi is when uric acid crystals around the joints ...

In some individuals, particularly the elderly, gout episodes become chronic, and crystals of uric acid metabolism byproducts are deposited over the affected joint, forming swellings known as tophi.

Left untreated, gout in the elbow can lead to permanent joint damage and tophi—painful bumps where uric acid crystals have ...

CRG is a painful and debilitating condition in people with persistent raised serum uric acid (sUA) levels, which may result in several flares per year and the development of nodular masses of uric ...

In the U.S., an estimated 13 million individuals are diagnosed with gout and approximately 2 million of those patients have visible tophi. In Phase II studies, AR882 demonstrated encouraging ...