TAXIS has developed a novel strategy consisting of targeting bacterial efflux pumps, a family of multi-protein complexes that span the bacterial cell membranes and act like bilge pumps that flush ...

Efflux pumps of the resistance-nodulation-division family: a perspective of their structure, function, and regulation in gram-negative bacteria. Efflux pumps of gram-negative bacteria: genetic ...

We have identified and developed compounds that act as bacterial efflux pump inhibitors (EPIs). Bacterial efflux is one of the primary mechanisms by which bacteria can develop resistance to current ...

Understanding how bacteria control the entry and efflux of chemicals helps us to explain and possibly reverse antimicrobial drug resistance. Even when antimicrobials gain access via porins, they are ...

For example, structures called "efflux pumps" in the cell membrane allow bacterial cells to pump out antibiotics that get inside the cell. Bacterial cells can also make enzymes that chemically ...

Explore the vital role of pathology in medicine, its impact on antimicrobial resistance, and the significance of International Pathology Day 2024.

In particular her team are interested in the study of efflux pumps as a mechanism of resistance ... his group specialises in the extreme recalcitrance of bacterial biofilms to antibiotics, notably ...

For instance, DNA methylation may regulate genes encoding efflux pumps—proteins that expel antibiotics from the bacterial cell—and genes involved in biofilm formation, which can shield bacterial ...

This resistance is attributed to the presence of genes encoding class D β-lactamases, such as OXA-23, which inactivate ...

circumvention of the target pathway or efflux of the antibiotic) and bacteria can develop resistance by mutating existing genes, or by acquiring new genes from other strains or species.

This important study explores the interplay between gene dosage and gene mutations in the evolution of antibiotic resistance. The authors provide solid evidence to connect proteostasis with gene ...

Currently we are focusing on the following studies: 1) Investigating the biofilm and drug resistance development; 2) Analyzing resistance genes in antibiotic resistant Enteric bacteria; 3) Developing ...