More than 140,000 articles have been published on molecules that mediate the intrinsic and extrinsic apoptotic cascades, such as BCL-2, TNF, NF-κB and p53. This interest in part stems from the ...

BAD is a pro-apoptotic member of the Bcl-2 family that is tightly regulated by survival factors. Several major signalling pathways influence cell death through their direct effects on the ...