Protein aggregation is the process by which misfolded proteins adopt a conformation that cause its polymerization into aggregates and organized fibrils. Many neurodegenerative diseases ...
Protein folding is the process by which proteins achieve their mature functional (native) tertiary structure, and often begins co-translationally. Protein folding requires chaperones and often ...
Pathogenic activating point mutations in the LRRK2 kinase cause autosomal-dominant familial Parkinsońs disease (PD). In cultured cells, mutant LRRK2 causes a deficit in de novo cilia formation and ...
The bar has a retro feel with an original wood floor, and booths repurposed from its prior establishment: a pharmacy in the 1930s. The Fox Bar values sustainability and seasonality, changing the ...