The type 1 IGF receptor (IGF-IR) is activated by two ligands, IGF-1 and IGF-2, and by insulin at supraphysiological concentrations. It plays a significant role in the growth of normal and abnormal ...
Insulin-like growth factor 1, also known as IGF-1, is a crucial hormone that significantly affects muscle development and rejuvenation. This hormone is generated by the liver in response to the ...
近期,福建医科大学第二附属医院神经外科团队于国际知名期刊《Medicine (Baltimore)》发布了一项荟萃分析。该分析结果显示,干细胞疗法在降低缺血性卒中患者的死亡率以及改善神经系统预后方面成效显著。 [2] ...
IRS-1 effects on cells can be dissociated from the effects of the IGF-IR, IRS-2 and insulin receptor. IRS-1 is a biomarker of sensitivity of cancer cells to IGF-IR targeting. Hypothesis ...
信达生物准备补齐最后一块短板。信达生物是国内创新药企效率之王,运营能力、临床速度都得到充分验证。然而,国际化意难平。对股价近两年徘徊在40元左右的信达生物而言,任何出海成功都是增量。10月25日晚,Fortvita作为信达生物推动国际业务的平台正式亮 ...
we treated weaver mice with GH for 2 weeks and found a signify cant increase in body weights and circulating IGF-I levels in weaver mice, but not in wild type mice. In summary, our results suggest ...
环球老虎财经专栏 on MSN8 天
信达生物“认错”,投资者选择原谅
11月3日晚间,信达生物发布公告称,决定不继续进行建议认购事项,Fortvita和Lostrancos已共同同意终止认购协议。11月4日一早,信达生物又紧急召开了业务更新说明会,对撤回交易事项进行进一步说明。不难看出 ...
信达生物将其产品线聚焦于癌症、免疫、心血管及代谢、眼科这四大领域。目前信达生物已有11个商业化产品,其中9个为抗肿瘤药(信迪利单抗、氟泽雷塞、伊基奥仑赛、贝伐珠单抗、利妥昔单抗、佩米替尼、奥雷巴替尼、雷莫西尤单抗、塞普替尼);代谢类1个(托莱西单抗) ...
尽管信达生物手握11款商业化产品,但除了氟泽雷塞和托莱西单抗面临的竞争环境相对良好,其余包括PD-1大单品信迪利单抗在内的产品均面临激烈的市场竞争,对于刚在2023年以36%的营收增长实现减亏的信达生物来说,想要维持稳健增长,还得不停地推出更具优势的 ...