Nearly every arthritis sufferer has taken a traditional painkiller like aspirin or Aleve. They are a great solution for relieving pain and inflammation, but there's a definite downside.

Celecoxib appears to be as effective as comparator NSAIDs in improving the signs and ... analgesic and anti-inflammatory activity to naproxen 500mg twice daily in a large-scale study of patients ...

Naproxen sodium 220mg, diphenhydramine HCl 25mg; caplets. Avoid concomitant other pain relievers. Naproxen may decrease effects of aspirin. Increased risk of GI bleed with anticoagulants ...