The clinical management of patients with HLRCC requires an integrated, multidisciplinary approach. Diagnostic evaluation of individuals who are suspected of having HLRCC includes a thorough ...

Germline mutations in a gene that encodes a Krebs cycle enzyme have been found to result in a distinct clinical entity referred to as hereditary leiomyomatosis and renal cell cancer (HLRCC).

"Overall, we found that patients with recurrent RCC following adjuvant IO continued to have responses to different types of first-line systemic therapy," says Talal El Zarif, MD.

These tumors exhibit a low-grade oncocytic morphology and have been linked to hereditary leiomyomatosis and renal cell carcinoma (HLRCC) syndrome. Immunohistochemical staining for 2-succinocysteine ...

Barata in the slide below: Next, Dr. Barata discussed the evidence for and treatment options for other nccRCC histologic subtypes. Patients with hereditary leiomyomatosis have fumarate hydratase (FH) ...