Germline mutations in a gene that encodes a Krebs cycle enzyme have been found to result in a distinct clinical entity referred to as hereditary leiomyomatosis and renal cell cancer (HLRCC).
These tumors exhibit a low-grade oncocytic morphology and have been linked to hereditary leiomyomatosis and renal cell carcinoma (HLRCC) syndrome. Immunohistochemical staining for 2-succinocysteine ...
The clinical management of patients with HLRCC requires an integrated, multidisciplinary approach. Diagnostic evaluation of individuals who are suspected of having HLRCC includes a thorough ...