此前的一些研究发现，通过遗传学或者药理学方法，消除以p16Ink4a（细胞周期蛋白依赖性激酶抑制蛋白）为标志物的衰老细胞，可以延长早衰小鼠的寿命，减轻衰老小鼠的年龄相关表型，改善多种年龄相关疾病。 然而，也有研究显示，完全清除衰老细胞并不是 ...

Zizyphi spinosi semen demonstrates neuroprotective effects, improving cognitive function and reducing amyloid and tau pathology in models of aging and dementia.

Every cell indicates a functional and morphological change that may be used as a biomarker of senescence. Senescence-associated β-galactosidase (SA-β-gal), cell cycle inhibitors (p16INK4a, p21CIP1, ...

【导读】前列腺癌是全球男性中第二常见的癌症。最近的研究强调了il6st介导的信号通路在各种癌症的发生和发展中发挥的关键作用，特别是通过过度激活的STAT3信号通路。然而，IL6ST/STAT3在前列腺癌中介导的分子程序尚不清楚。10月31日，奥地利维 ...

你是否知道，前列腺癌是全球男性中第二常见的癌症？每年有超过140万的新发病例，相关死亡病例达37.5万。面对如此严峻的形势，科学家们一直在寻找更有效的治疗方法。最近，奥地利维也纳医科大学与德国基尔大学的研究人员合作发表了一项突破性的研究成果，这一发现可能会彻底改变我们对前列腺癌治疗的传统观念。 想象一下，如果你被告知有一种新的方法可以显著降低前列腺癌的发展风险，你会不会感到惊讶和好奇呢？这项研究正 ...

The appearance and behaviour of cells are determined by the genes expressed in that cell. The abnormal behaviour of cancer cells can thus be explained by invoking quantitative and/or qualitative ...

aDepartment of Molecular Medicine and the Center on Aging, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL 33458, United States bRobert and Arlene Kogod Center on Aging, Mayo Clinic, 200 ...

In penile cancer, the overexpression of p16INK4a was associated with the presence of hrHPV and basaloid subtype tumors (31). Moreover, studies indicate that p16INK4a expression triggers a ...