Catharina Svanborg and colleagues have shown that differential expression of Toll-like receptor 4 (TLR4), driven by variations in the sequence of the gene's promoter, affects the magnitude of the ...

In addition, Poltorak et al. (1998) demonstrated that mice with a defective version of TLR4 are completely resistant to LPS-induced sepsis. This established that TLR4 is the receptor for LPS ...

They found that microbes from aged mice were more likely than those from young mice to activate TLR4, which can sense ...

Once released extracellularly, it binds to receptors such as RAGE and TLR4, amplifying inflammatory signaling and ...

Learn about HMGB1's crucial role in liver diseases, its pathways and therapeutic potential that can treat liver diseases.

名称：表达Toll样受体4 ( TLR4)的巨噬细胞膜包裹负载抗菌剂的纳米颗粒目 录 号：ML-定制 说明：Toll 样受体 4 (TLR4) 是一种重要的免疫受体，属于 Toll 样 ...

Liver diseases, both acute and chronic, continue to pose significant clinical challenges due to high morbidity and mortality ...

LPS泛菌糖脂质作为一种优质的免疫营养，受到了广泛关注。 它主要存在于天然植物中，如全谷物、海草及中草药等。 通过激活吞噬细胞表面的TLR4受体，以及诱导NK细胞、T细胞的活性化，共同发挥消灭ai细胞的重要作用。 这一发现也为布鲁斯•博伊特勒、朱尔斯 ...

*仅供医学专业人士阅读参考在我们的肠道中，微生物群通过合作和竞争机制维持平衡，一旦失调便会发生有害微生物的异常增殖，持续毒性代谢产物。肠道微生物的生态失衡，甚至可以影响到遥远的中控系统，也就是我们的大脑。近日，葡萄牙科英布拉大学的Nuno ...

“我们的研究发现，通肠清胰汤能够减少促炎性因子的分泌，保护肠道黏膜屏障，减轻胰腺、肺部及回肠、结肠组织的病理损伤。”中医的疗效并非凭空而来，章茜医生在论坛上也分享了相关的科研结果，“这可能与调控TLR4/NF-κB信号通路有关，该通路在急性胰腺炎的发 ...

Also like Shingrix, amezosvatein uses an adjuvant targeting the TLR4 pathway to boost the immune response to the gE antigen. Amezosvatein was engineered to have a best-in-class safety profile in ...

▎药明康德内容团队编辑  每年，全球有数十万人死于心肌纤维化导致的疾病。心肌纤维化是由于长期过量生产纤维材料而使心脏组织变硬、出现瘢痕，会损害心脏的正常功能。作为心力衰竭的重要诱导因素，心肌纤维化缺少有效的临床治疗方法。在《细胞》近期上线的一篇研究论 ...