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Thyroxine (T4) is the principal hormone secreted ... is mediated primarily by T3 that is produced in situ from the free T4 entering the thyrotroph cells. Technically, it has been easier to develop ...

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The diagnosis and treatment also differ. Hyperthyroidism may involve the thyroid gland itself or a pea-sized organ in the brain called the pituitary gland which directs the secretion of T3 and T4.