Efavirenz is an important drug for treating HIV infection, but it has negative effects that can significantly impact patients' quality of life over time. It causes neuropsychiatric disorders and ...

Efavirenz is an important drug for treating HIV infection, but it has negative effects that can significantly impact patients ...

Spanish researchers found that high plasma efavirenz levels correlated with CNS symptoms even after weeks or months of treatment. However, in a substudy of an ACTG trial, late neuropsychiatric ...

Patients stopping efavirenz-based combination therapy might be well advised to continue their NRTIs for 24 to 48 hours after discontinuing efavirenz to avoid prolonged NNRTI monotherapy.

Researchers have identified how the HIV drug Efavirenz causes neuropsychiatric disorders and neurocognitive impairment, ...

This is figure 4 from a paper in ACS Pharmacology & Translational Science that used a novel approach to show changes in lipid metabolism and protein expression as a result of treatment with the HIV ...

These findings, among others in the paper, may pave the way to developing drugs that mitigate brain toxicities associated with Efavirenz. (ACS Pharmacol. Transl. Sci. 2024, 7, 8, 2379-2390 ...

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