Our laboratory sits at the interface between stem cell biology and developmental neuroscience. We use pluripotent stem cells to model neurological development and disease with a specific focus on ...

The first wave channels glucose through the hexosamine biosynthetic pathway (HBP) in epiblast cells, facilitating the formation of proteoglycans for fibroblast growth factor (FGF) signaling.

Dr. Donald and Ruth Weber Goodman Professor of Innovative Therapeutics Our laboratory sits at the interface between stem cell biology and developmental neuroscience. We use pluripotent stem cells to ...

The epiblast of vertebrate embryos is comprised of neural and non-neural ectoderm, with the border territory at their intersection harboring neural crest and cranial placode progenitors. Here, we a ...

In mouse embryo gastrulation, epiblast cells delaminate at the primitive streak to form mesoderm and definitive endoderm, through an epithelial-mesenchymal transition. Mosaic expression of a membrane ...