These findings suggested that inflammation and excitotoxicity could play a role in secondary brain injury (Castillo et al., 2002; Mayer & Rincon; Rincon & Mayer, 2004). Another theory suggests ...

Pathologically high levels of extracellular glutamate can cause excitotoxicity, when postsynaptic receptors such as NMDA and AMPA are overactivated, allowing high levels of calcium influx that trigger ...

His lab first discovered that excitotoxicity might be a common pathophysiological process in sporadic ALS, which led to the use of the drug riluzole as a treatment for ALS. Rothstein made discoveries ...

The antipsychotic drug haloperidol is often used in emergency care to treat psychoses induced by methamphetamine, but a recently published animal study by Hatzipetros et al. warns that this ...

The researchers for the new study also noted that riboflavin is known to improve "oxidative stress, mitochondrial dysfunction, neuroinflammation, and glutamate excitotoxicity," all of which are ...

and excitotoxicity. More than 40 studies have used progesterone for treatment after traumatic brain injury in adult animal models, with results summarized in tabular form. However, very few ...

The mechanism, says So, is probably the L. barbarum polysaccharides’ ability to reduce excitotoxicity, which damages neurons through an overactivation of receptors by glutamate, the primary ...

In recent years, peptides have emerged as critical players in various fields of biological and molecular research. Among ...

Chapp AD, Behnke JE, Driscoll KM, Fan Y, Hoban E, Shan Z, Zhang L, Chen QH*. Acetate Mediates Alcohol Excitotoxicity in Dopaminergic-Like PC12 Cells. ACS Chem Neurosci 2019 Jan 16;10(1):235-245. 6. Wu ...