Other DYRK-family kinases were not found in stable Hsp90 associations, although a kinase-inactivating mutation converted DYRK2 into a geldanamycin-sensitive Hsp90 client. Together, these studies ...
A specific class of drugs — benzoquinoid ansamycins, which include the drugs herbimycin A and geldanamycin — helped make it clear. These drugs are useful for research purposes because they ...
Treatment of chronic myeloid leukemia (CML) has changed drastically with the emergence of the Abl tyrosine kinase inhibitor (TKI), imatinib mesylate. However, primary and secondary resistance have ...