"When you're dealing with a large explosion like this, and such a massive amount of destruction, it's going to be difficult," one official said.

At least 11 people were injured in Louisville, Kentucky, after an explosion in a neighborhood east of the city's downtown area. Officials said there was a “hazardous materials incident” at a company that makes natural food colorings.

Kentucky officials issued a shelter-in-place order after an explosion was heard at a Louisville plant in the city's Clifton neighborhood. (Source: WDRB)