The late stages of the development of T1DM, characterized by stabilization and maintenance of insulitis or, in some cases, its resolution, are probably dominated by the adaptive immune response.

A crucial transition, which probably takes place in the early stages of insulitis, determines whether the initial inflammatory response will lead to a full-fledged adaptive immune response ...

Type 1 diabetes is an immune-mediated disease in which pancreatic insulin-producing beta cells are damaged and destroyed. Animal models have served a prominent function in the development of the ...

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Islet transplantation (ITx) is an effective means to restore physiologic glycemic regulation in those living with type 1 diabetes; however, there are a handful of barriers that prevent the broad ...

1 Department of Neurology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Institute of Neuroimmunology, Shandong Provincial Key ...

Correspondence to: Professor R J Looney, University of Rochester, 601 Elmwood Avenue, Rm G-6454, Rochester, NY 14642, USA; John_Looney{at}URMC.Rochester.edu B cells are by definition the source of all ...