The AI tool AlphaFold has been improved so that it can now predict the shape of very large and complex protein structures.

Jennifer Hudson‘s first Christmas album, The Gift of Love, has debuted on Billboard’s Top Holiday Albums chart this week. The ...

Researchers from Linköping University enhanced the AI tool AlphaFold to predict the shape of extremely large and complex ...

引言通过化学小分子诱导靶蛋白和E3泛素连接酶的相互作用，从而实现靶蛋白的特异性降解是一种新兴的药物开发模式，为传统上被认为“难以成药”的靶点提供了全新的解决方案。当前用于靶向蛋白降解的化学分子主要分为两类：蛋白降解靶向嵌合体(PROTAC)和分子胶( ...

The AI tool AlphaFold has been improved so that it can now predict the shape of very large and complex protein structures. Researchers have also succeeded in integrating experimental data into the ...

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The AI tool AlphaFold has been improved so that it can now predict the shape of very large and complex protein structures. Linköping University researchers have also succeeded in integrating ...

靶向蛋白质降解（TPD） 通过促进疾病相关蛋白质与 E3 泛素连接酶的相互作用来消除这些蛋白质。其可以选择性地降解细胞内的特定蛋白质，而异常的蛋白质聚集与神经退行性疾病、自身免疫和癌症有关。目前有两大类化学降解剂用于 TPD：分子胶（MGs）和蛋白降解靶向嵌合体（PROTACs）。PROTAC 由靶蛋白配体、连接子和 E3 ...