Implications for gene regulation and biomedicine The study demonstrates that nucleosomal architecture is greatly influenced by the DNA sequence and physical signals that are emitted by the ends of ...

As its name suggests, the fifth histone is associated with the linker DNA that extends between nucleosomal core particles. We will use the name 'linker histone' to include all the closely related ...

Our group applies structural (cryo-EM, x-ray crystallography and NMR), biochemical and biophysical methods together with functional studies to investigate macromolecular-mediated recognition, ...

These attendant proteins bind to histones and nucleosomal DNA, and their binding to these molecules is affected by the histone modification state. The modification state helps determine whether ...

Yeying Huang, R. Taylor Durall, Nhi M. Luong, Hans J. Hertzler, Julianna Huang, Prafulla C. Gokhale, Brittaney A. Leeper, Nicole S. Persky, David E. Root, Praju V ...