The demonstrated ability of modern DNA-dependent RNA polymerases to use RNA templates for productive RNA synthesis suggests that they evolved from ancient RNA-dependent RNA replicases. Figure 1 ...

Studies in other groups are in progress to determine the basis of resistance that is conferred by expression of genes encoding viral replicases and other proteins. Many such studies also include ...

We examine a variety of DNA polymerases including human DNA polymerases and telomerase; eubacterial and archaeal DNA polymerases; and viral replicases and reverse transcriptases. The work addresses ...

The currently developed RNA-based replicases are, however, very inefficient (as compared to protein-based polymerases) and ...