This important study using engineered mouse models provides a first and compelling demonstration of a pathogenic phenotype associated with lack of expression of p53AS, an isoform of the p53 protein ...

The excessive cosolute densities in the intracellular fluid create a physicochemical condition called macromolecular crowding (MMC). Intracellular MMC entropically maintains the biochemical ...

Sickness-induced sleep is a behavior conserved across species that promotes recovery from illness, yet the underlying mechanisms are poorly understood. Here, we show that interleukin-6-like cytokine ...

This theoretical study makes a useful contribution to our understanding of a subtype of type 2 diabetes – ketosis-prone diabetes mellitus (KPD) – with a potential impact on our broader understanding ...

Behavioral studies reveal that bumblebees distinguish between continuous and interrupted strings by using a combination of image matching and associative learning.

Department of Neurology, Weill Institute for Neuroscience, University of California San Francisco, San Francisco, California Department of Psychiatry, Weill Institute for Neuroscience, University of ...

For the first time, a molecular mechanism is identified, for experimental acceleration and deceleration (rejuvenation) of sperm epigenetic aging.

This study presents a valuable finding on the function of the gene Cst7 in sex-divergent pathological changes in microglia in a mouse model of amyloid-driven Alzheimer's disease. The evidence ...

National Research Center for Protozoan Diseases, Obihiro University of Agriculture Veterinary Medicine, Inada-cho, Obihiro, Japan Department of Veterinary Medicine, Agriculture College of Yanbian ...

Pipettes and Problem Solving is an initiative that teaches some of the skills needed to figure out why an experiment is producing unexpected results.

After nerve injury, myelin and Remak Schwann cells reprogram to repair cells specialized for regeneration. Normally providing strong regenerative support, these cells fail in aging animals, and during ...

Chromatin accessibility discriminates stem from mature cell populations, enabling the identification of primitive stem-like cells in primary tumors, such as glioblastoma (GBM) where self-renewing ...