最近对全基因组染色质相互作用的研究表明，人类基因组被划分为许多自关联的拓扑结构域。 结构域之间的边界序列富含 CTCC 结合因子 (CTCF) 和粘连蛋白复合物的结合位点，暗示这两个因素参与拓扑结构域的建立或维持。 为了确定粘连蛋白和 CTCF 在人类细胞高阶 ...

胚胎干细胞在再生医学中的前景是基于它们具有制造体内每个细胞的潜力，这种特性被称为多能性。 随着技术的快速进步，从成体组织中制备胚胎干细胞样系变得相对简单。 在不久的将来，这些细胞系的产生将变得越来越普遍，包括生产可用于评估疾病甚至 ...

HiDef-B8 通过降低成本（300 美元/L）和每周需要更少的通道（1-2 次而不是 3-5 次）来解决扩大生产的问题。 行动机制 HiDef-B8 经过了广泛的经验优化和替代成分筛选，重点是降低成本、保持 iPS 细胞的多能性和稳健性，并实现无周末、最小传代干细胞培养。 其中 ...

CIRM Announces Recommendations from Strategic Allocation Framework. South San Francisco, CA, September 27, 2024 – The California Institute for Regenerative Medicine (CIRM), one ...

Dr. Xianmin Zeng, associate professor at the Buck Institute for Research on Aging answers your questions about Parkinson’s disease and stem cell research. Zeng has a CIRM research grant to develop a ...

Members of the public who are listening to the meeting and wish to make a comment will have the opportunity to do so by doing the following: Once we have called for public comment, members of the ...

Members of the public who are listening to the meeting and wish to make a comment will have the opportunity to do so by doing the following: Once we have called for public comment, members of the ...

We will uncover pathways through which ASD mutations cause disease and close the gap from disease research to therapeutic testing using organoids, primary human neurons, machine learning and AAVs. Our ...

Members of the public who are listening to the meeting and wish to make a comment will have the opportunity to do so by doing the following: Once we have called for public comment, members of the ...

We propose to apply scalable platforms for the characterization of CNVs and genes coupled with detailed characterizations of neurodevelopment of the 4 major CNV loci in model systems and patients. A ...

Meetings of the Grants Review Working Group will be held in a public session format except for the review of individual grant applications which will be conducted in closed session. THE ORDER OF ...

单细胞技术对于推动基础和转化研究皮肤病学的发现至关重要。尽管有大量可用的数据集，但仍然缺乏正常人类皮肤的中央参考图集，它可以作为皮肤细胞类型、细胞状态及其分子特征的参考资源。对于任何这样的图集获得广泛接受，许多研究人员参与图集构建 ...