Total hip replacement is routinely recommended for severe hip osteoarthritis, but data from randomized trials are lacking ...

Hairy-cell leukemia (HCL) is a rare, indolent neoplasm of mature B cells with hairlike surface projections that circulate in the blood and preferentially infiltrate the bone marrow and spleen.

In 2011, the International Federation of Gynecology and Obstetrics published a fibroid classification system to better describe the location of fibroids in relation to the uterine cavity and the ...

Weight reduction has been shown to alleviate symptoms of osteoarthritis of the knee, including pain. The effect of glucagon-like peptide-1 receptor agonists on outcomes in knee osteoarthritis ...

The Race and Medicine collection reflects NEJM’s commitment to understanding and combating racism as a public health and human rights crisis. Our commitment to antiracism includes efforts to ...

Although lead has been mined for 6000 years, lead processing skyrocketed in the 20th century. 1,8 A malleable and durable metal, lead was used to prevent fuel from burning too quickly and to ...

Welcome and thank you for considering the New England Journal of Medicine (NEJM) as a venue for your work. As the oldest continuously-published medical journal, our mission since 1812 has been to ...

There is growing concern about the well-being of physicians and the consequences of poor well-being for physicians themselves, their patients, and the broader health care system. Diminished well ...

Artificial Intelligence (AI) has tremendous potential to advance clinical practice and the delivery of patient care. A new Review article series, “AI in Medicine,” explores the role of AI ...

Kidney transplantation from donors with human immunodeficiency virus (HIV) to recipients with HIV is an emerging practice. It has been performed since 2016 under the U.S. congressional HIV Organ ...

For patients with asymptomatic severe aortic stenosis and preserved left ventricular ejection fraction, current guidelines recommend routine clinical surveillance every 6 to 12 months. Data from ...