Activation of macrophage TLR4 by bacterial endotoxins is important for the progression of sepsis, but the underlying ...

Lysine acetylation, a reversible post-translational modification, is catalyzed by lysine acetyltransferases (KATs) and lysine deacetylases (KDACs). Proteins comprising evolutionarily conserved ...

Post-translational modifications (PTMs) of α-synuclein (α-syn) such as acetylation and phosphorylation play important yet distinct roles in regulating α-syn conformation, membrane binding, and amyloid ...

The findings demonstrate the essential contribution of the microtubule network to changes in cell shape driven by mechanical forces. Furthermore, we observed a flow-dependent increase in microtubule ...

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A research team, delving into the impact of excessive prenatal prednisone exposure (PPE) on fetal development, discovered ...

The sequencing of the human genome at the turn of the 21st century was heralded as a monumental scientific achievement ...

Diffuse midline glioma (DMG) is a highly aggressive and fatal pediatric high-grade glioma that primarily affects critical ...

Epigenetics regulates gene expression through modifications, impacting health and disease. Aberrant patterns can lead to ...

Key findings include the discovery of active genic states enriched with acetylation marks like H3K9/K14ac and H3K27ac, which are associated with genes involved in anthocyanin accumulation ...