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中国科学院
15 天
营养与健康所等发现在翻译水平调控T细胞死亡的关键因子
这一翻译控制通路可在T细胞活化后通过CD28-PI3K-mTORC1-eIF4F轴增强AMBRA1翻译,调节FAS和其他免疫相关基因的表达。 进一步,科研人员利用一系列蛋白互作和翻译水平检测技术如Bio-ID、SunSET、SILAC并结合mePROD等发现,AMBRA1与多个核糖体蛋白互作,促进多种核糖体生物 ...
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