The chaperones Hsp70 and Hsp90 cooperate in the folding and maturation of a subset of proteins that includes protein kinases, steroid hormone receptors (such as the glucocorticoid receptor), and ...

The balance of protein folding and degradation is one of the most fundamental activities of the cell, and is a critical point of intervention in cancer, metabolic, and aging diseases. Molecular ...

Protein folding requires chaperones and often involves stepwise establishment of regular secondary and supersecondary structures, namely α-helices and β-sheets, that fold rapidly, stabilized by ...

They revealed crucial new details about how the chaperone works alongside a partner – called CDC37 – to carry out its job and keep cancer cells growing. Until now, researchers have focused their ...

Therefore, cells have mechanisms in place to control protein quality ... Among their several roles, chaperone proteins like Hsp70s typically assist the correct folding of proteins.

Researchers identified a non-genetic mechanism at the base of this new multicellular trait, which acts at the level of ...

Heat shock proteins (HSPs) are the chaperones of cellular stress response because they help guide the folding and unfolding of other proteins ... Humans possess up to 17 variations of this protein, ...