Trends in Genetics 22, 46–55 (2006). Argueso, J. L. et al. Double-strand breaks associated with repetitive DNA can reshape the genome. Proceedings of the Naitonal Academy of Sciences 105 ...

A new study in Nature identifies a long-sought cytoplasmic 'sensor' that is responsible, at least in part, for interferon responses induced by double-stranded DNA. How do cells detect non-self ...

Homologous recombination plays essential roles in the repair of DNA double strand breaks (DSBs) and collapsed replication forks. The fundamental reaction in homologous recombination is the exchange of ...

Scientists at Vilnius University have developed a novel gene silencing method using a type IV-A CRISPR system that silences ...

这项在模式动物秀丽隐杆线虫中进行的研究显示，接触常用的塑化剂邻苯二甲酸苄丁酯（BBP），会导致氧化应激增加和DNA双链断裂增加，进而损害生殖细胞的基因组完整性和染色体分离，导致生殖细胞 功能障碍 。

The requested information must be provided to the core and the core must approve the approach prior to proceeding to the next steps. For cytoplasmic injections the mix will contain the guide RNA(s), ...

Life Sciences Center (LSC) have discovered a unique way for cells to silence specific genes without cutting DNA. This research, led by Prof. Patrick Pausch and published in the journal Nature ...

For additional resources to assist in donor production, contact the core. It is recommended that the investigator request this service once they have a suitable donor DNA ready for microinjection. It ...

Efficient DNA repair mechanisms are essential for bacterial survival ... albeit at the cost of genomic stability. Role in ...

DNA stands for deoxyribonucleic acid. Nucleic acids are named for where they're found—inside the nuclei of cells—and for the ...

Biology lectures teach students that when a cell’s replication machinery comes together, DNA polymerase takes off down the double-helix like a car on a highway ...

The "RNA world" hypothesis proposes that the earliest life on Earth may have been based on RNA—a single-stranded molecule ...