编辑丨王多鱼排版丨水成文衰老是所有成年人不可避免的过程，往往会导致运动功能下降，例如不稳定的步态、虚弱，甚至难以完成日常活动。骨骼肌的收缩和运动是由运动神经元通过神经肌肉接头（NMJ）控制的，这是运动神经元与肌肉纤维之间的突触连接。随着年龄增长，肌肉 ...

该研究表明Sirt6蛋白在老年小鼠肌肉中降低，在骨骼肌中敲除Sirt6导致抗肌萎缩蛋白Dystrophin蛋白水平降低，导致过早的神经肌肉接头（NMJ）退化变性 ...

Duchenne muscular dystrophy is a severe and progressive disorder caused by mutations in the dystrophin (DMD) gene that lead to malfunction or absence of dystrophin. This protein stabilizes the ...

The US biopharma will discontinue development of the Exondys 51 (eteplirsen) follow up treatment to focus on other treatment ...

Regulating drug discovery and pharmaceutical manufacturing, the FDA ensures the safety and effectiveness of innovative ...

A Phase 3 clinical trial investigating Elevidys (delandistrogene moxeparvovec), a gene therapy for Duchenne muscular ...

In this condition, patients' bodies don't make enough for the dystrophin protein necessary to keep muscles intact. Sarepta ...

重点推荐扫码下载《动物行为实验手册》pdf斑马鱼肌少症模型是研究肌肉减少症状的重要工具，其建立方法和应用在学术界受到了关注。斑马鱼由于其许多突出的优点，十多年来一直被用作衰老研究的模型。斑马鱼的肌少症模型为理解肌少症的发病机制提供了重要的工具，有助于发现新的治疗策略。斑马鱼肌少症模型在理解肌少症的发病 ...

Furthermore, impressive results in the DMD program, particularly in exon skipping and dystrophin expression, exceeded expectations, positioning Avidity Biosciences favorably for regulatory discussions ...

Elevidys sales have increased since the FDA made a controversial choice to expand the therapy's use. Meanwhile, Sarepta is ...