TAXIS has developed a novel strategy consisting of targeting bacterial efflux pumps, a family of multi-protein complexes that span the bacterial cell membranes and act like bilge pumps that flush ...

Efflux pumps of the resistance-nodulation-division family: a perspective of their structure, function, and regulation in gram-negative bacteria. Efflux pumps of gram-negative bacteria: genetic ...

Understanding how bacteria control the entry and efflux of chemicals helps us to explain and possibly reverse antimicrobial drug resistance. Even when antimicrobials gain access via porins, they are ...

For example, structures called "efflux pumps" in the cell membrane allow bacterial cells to pump out antibiotics that get inside the cell. Bacterial cells can also make enzymes that chemically ...

For instance, DNA methylation may regulate genes encoding efflux pumps—proteins that expel antibiotics from the bacterial cell—and genes involved in biofilm formation, which can shield bacterial ...

In particular her team are interested in the study of efflux pumps as a mechanism of resistance ... his group specialises in the extreme recalcitrance of bacterial biofilms to antibiotics, notably ...