Rate this content's potential impact on patient outcomes Submit Rating Thank you! Please share some more information on the ...

More information: Dongkyun Kim et al, Inhibitory co-receptor Lag3 supports Foxp3+ regulatory T cell function by restraining ...

在健康的肠道中，免疫系统如同一支完美的管弦乐队，各种细胞默契配合，维护着身体的和谐。然而，面对克罗恩病（CD）等炎症性肠病（IBD）的干扰，这种平衡状态被打破，打击了无数患者的生活质量。克罗恩病这一慢性、复发性疾病不是孤立存在的，它的发病率正在全球范围内悄然上升。那么，这种疾病是如何影响我们的健康的？它的治疗又有哪些新的进展？ 克罗恩病的现状与挑战克罗恩病的病因复杂，涉及遗传、环境、免疫等多方面因 ...

Four studies examine this question, delving deeply into the role of the transcription factor Foxp3 in governing Treg differentiation and function. Tregs play essential roles in immune homeostasis ...

Coya Therapeutics' stock has sold off on misinterpreted data from a small trial with COYA 301, creating a good buying ...

Their focus was to understand the mechanisms that support the expression of a protein named Foxp3, a transcription factor known to control Tregs’ suppressive activity. “Foxp3 is the pinnacle ...

【导读】免疫检查点阻断（ICB）疗法已成为多种晚期癌症的新治疗范式，但由于低响应率，其广泛的临床应用受到了阻碍。在这项研究中，团队采用了一种基于肽的、仿生的、自组装策略，制造了一种纳米颗粒TPM1，用于结合肿瘤细胞表面的PD-L1。2024年11月9 ...

The image below describes the main parts of both workflows on the basis of a colon sample stained with DAPI and for FOXP3, CD25 and CD4.

Our analysis of DNase-seq data in the T cell lineage and of Foxp3 ChIP-seq in regulatory T cells (Tregs) revealed that many Foxp3-bound loci are DNase accessible not only in Tregs but also in CD4+ T ...

Coya Therapeutics reports mixed data from Phase 2 study of low-dose IL-2 in Alzheimer's, showing safety and potential cognitive benefits in q4wks regimen.

调节性T（Treg）细胞是免疫系统中的一种特殊T细胞亚群，负责维持免疫耐受性和防止自身免疫性疾病的发生。它们通过抑制过度的免疫反应，避免对自身组织发起攻击。Treg细胞特异性表达Foxp3转录因子，并通过分泌抑制性细胞因子（如IL-10和TGF-β） ...

阔然生物推出的一站式NGP检测方案可对高级别浆液性卵巢癌的肿瘤微环境进行全面解析，检测方案可纳入CD8、CD3、CD45、Foxp3、CD56等指标深入研究HGSC免疫逃逸机制以及去抑制HGSC癌症免疫原性的新方法。