Little is known about discrete cell types and molecular mechanisms in PTOA synovium. We aimed to describe synovial cell populations and their dynamics in PTOA, with a focus on fibroblasts. We also ...

Objectives Fibroblasts in synovium include fibroblast-like synoviocytes (FLS) in the lining and Thy1+ connective-tissue fibroblasts in the sublining. We aimed to investigate their developmental origin ...

Scarring of heart tissue can be slowed but not stopped, and can lead to heart failure. But a new study has shown that an ...

Read on to discover ten compelling reasons why you should consider adding vitamin C serum to your arsenal of beauty products.

Retinal, a derivative of vitamin A, works in various ways to improve the appearance of your skin. Here’s how to determine how ...

Some patients being treated with immune checkpoint inhibitors, a type of cancer immunotherapy, develop a dangerous form of heart inflammation called myocarditis. Researchers have now uncovered the ...

The Human Tumor Atlas Network leverages scientific collaboration to integrate samples, analytical modalities and tools into detailed atlases of tumor evolution. Expanding our spatial understanding ...

本研究论文的共创作者Tanimizu Naoki博士总结道，“目前，胰腺导管腺癌的抗癌药物在临床试验阶段都以失败告终。因此，具有独特肿瘤微环境特征的胰腺癌类器官的出现，应用于抗癌药物的筛选。 增殖性胰腺癌肿瘤类器官呈现出的耐药性及增殖潜能， ...

Researchers at the University of Virginia have discovered a new mechanism driving drug resistance in pancreatic ductal ...

The heart tissue showed upregulation of molecular pathways that help recruit and retain immune cells involved in inflammation. Patients with active disease also had greater abundance of clusters of ...