Germline mutations in a gene that encodes a Krebs cycle enzyme have been found to result in a distinct clinical entity referred to as hereditary leiomyomatosis and renal cell cancer (HLRCC).
The clinical management of patients with HLRCC requires an integrated, multidisciplinary approach. Diagnostic evaluation of individuals who are suspected of having HLRCC includes a thorough ...
These tumors exhibit a low-grade oncocytic morphology and have been linked to hereditary leiomyomatosis and renal cell carcinoma (HLRCC) syndrome. Immunohistochemical staining for 2-succinocysteine ...