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转自:生物谷(维权)
不同于其他体外细胞培养模型,这种新系统使用的是原代人类肝细胞而非常见的永生化细胞系。 研究人员直接从供体肝脏中分离出细胞,并在3D胶原三明治系统中进行培养,这样可以保持肝细胞典型的双相结构,从而保留了细胞类型特异性和代谢功能(如糖类和脂肪代谢)。
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