【导读】了解对化学扰动的转录反应是药物发现的核心，但对疾病-化合物组合进行详尽的实验筛选是不可行的。为了克服这一限制，团队在这里介绍了PRnet，这是一种扰动条件的深度生成模型，可预测对新型化学扰动的转录反应，这些扰动从未在批量和单细胞水平上进行过实 ...

PRnet确定了针对小细胞肺癌的活性化合物 02 鉴于SCLC的几种新型细胞系，即NCI-H69、NCI-H526、NCI-H446、NCI-H209和NCI-H196，以及DMS114，团队首先使用PRnet，预测SCLC细胞系对敏感化合物的转录反应。然后，团队在计算机中筛选了两个用户定义的化合物库，以确定针对SCLC的 ...

Cuffing season has begun! Venus’ entrance to Capricorn solidifies a love affair. This paramour is exactly who they claim to be. You may be looking for a love to last you through the winter, but ...

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What are national programmes of care? The specialised services commissioned by NHS England have been grouped into six national programmes of care (NPoC). Each has an NPoC that coordinates work across ...

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He is known to be one of the premier China hawks on Capitol Hill but takes a more middle-of-the-road position on Ukraine. The Netherlands faces down antisemitic violence once again. The contract ...